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. 2014 Jun 1;5(13):4881–4894. doi: 10.18632/oncotarget.2051

Figure 2. Anti-proliferative activities of IRE1αinhibitors.

Figure 2

(A) The effect of STF (50 μM) and HNA (50μM) on the cell growth of 6 pancreatic cancer cell lines compared to diluent treated controls (designated as 100%). Pancreatic cancer cell lines were treated with indicated drugs for 3 days, and cell viability was determined by MTT assays. (B) IC50s of HNA, 3ETH, and toyocamycin were determined using a series of concentrations (1 nM to 100 μM) of these drugs against a panel of pancreatic cancer cell lines using MTT assays. The IC50s were calculated with non-linear regression analysis using GraphPad Prism as described in Materials and Methods. R: Resistant at > 50 uM; n.d.: not done.