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. 2014 Apr 24;57(16):6919–6929. doi: 10.1021/jm5001425

Chart 3. Select Early AMT Analogues Evaluated for Brain Exposure in Micea.

Chart 3

a The EC50 values shown are for the ScN2a-cl3 assay, while brain AUC values reflect analysis of total brain homogenate following a single oral dose of 40 mg/kg in mice.50