Table 1. Pseudo Steady-State Brain Concentrations of Selected AMTs after 3-Day Dosing in a Liquid Rodent Diet at Various Daily Doses50,a.
brain concentration (μM) after 3 days at the indicated dose |
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---|---|---|---|---|
compd | 40 mg kg–1 day–1 | 80 mg kg–1 day–1 | 130 mg kg–1 day–1 | 210 mg kg–1 day–1 |
7 | 8.70 ± 1.46 | 19.3 ± 2.28 | 31.8 ± 5.46 | 37.4 ± 9.06 |
8 | 3.00 ± 0.52 | 7.45 ± 1.00 | 13.0 ± 2.81 | 19.3 ± 3.24 |
13 | 0.02 ± 0.03 | 0.08 ± 0.03 | 0.04 ± 0.03 | 0.10 ± 0.07 |
15 | 0.03 ± 0.03 | 0.06 ± 0.07 | 0.14 ± 0.04 | 0.32 ± 0.11 |
18 | 1.31 ± 0.39 | 2.70 ± 0.52 | 3.74 ± 0.41 | 3.23 ± 2.62 |
20 | 0.88 ± 0.68 | 5.39 ± 2.93 | 23.3 ± 13.2 | 12.6 ± 8.62 |
Drug concentrations are for total brain homogenate.