. 2014 Apr 24;57(16):6919–6929. doi: 10.1021/jm5001425

Table 1. Pseudo Steady-State Brain Concentrations of Selected AMTs after 3-Day Dosing in a Liquid Rodent Diet at Various Daily Doses⁵⁰^,^a.

	brain concentration (μM) after 3 days at the indicated dose
compd	40 mg kg^–1 day^–1	80 mg kg^–1 day^–1	130 mg kg^–1 day^–1	210 mg kg^–1 day^–1
7	8.70 ± 1.46	19.3 ± 2.28	31.8 ± 5.46	37.4 ± 9.06
8	3.00 ± 0.52	7.45 ± 1.00	13.0 ± 2.81	19.3 ± 3.24
13	0.02 ± 0.03	0.08 ± 0.03	0.04 ± 0.03	0.10 ± 0.07
15	0.03 ± 0.03	0.06 ± 0.07	0.14 ± 0.04	0.32 ± 0.11
18	1.31 ± 0.39	2.70 ± 0.52	3.74 ± 0.41	3.23 ± 2.62
20	0.88 ± 0.68	5.39 ± 2.93	23.3 ± 13.2	12.6 ± 8.62

Drug concentrations are for total brain homogenate.

Table 1. Pseudo Steady-State Brain Concentrations of Selected AMTs after 3-Day Dosing in a Liquid Rodent Diet at Various Daily Doses50,a.