Table 3. Inhibition of SP100030 Analogues on AP-1 and NF-κB Mediated Transcriptional Activation in Luciferase Reporter Assays on Jurkat T-Cells.

	IC50, μM
compd	AP-1	NF-κB
1	0.05	0.05
2	0.50	0.50
3	0.1	0.4
4	>10	>10
5	>10	>10
6	0.02	0.05
7	0.2	0.6
8	0.4	0.4
9	>10	>10
10	>10	>10
11	>30	>30
12	10	10
13	1.7	1.7
14	4.0	4.0
21	10	10
22	9.4	13
23	9.4	24
24	6.1	4.2
25	8.5	8.0
26	10	10
27	1.9	1.3
28	0.1	0.2