Table 5. Inhibition of SPC-839 Analogues on AP-1 and NF-κB Mediated Transcriptional Activation in Luciferase Reporter Assays on Jurkat T-Cells.

	IC50, μM
compd	AP-1	NF-κB
29	2	2
30	0.3	0.3
31	0.4	0.4
32	0.035	0.035
33	0.045	0.045
34	0.21	0.21
35	4.4	4.4
36	0.098	0.098
37	0.83	0.83
38	0.76	0.76
39	1	1
40	0.1	0.1
41	0.02	0.02
42	0.008	0.008
43	0.003	0.003