Fig. 5.

Closest mean classification of face and mid-line profile for individual with duplication of 17p11.2 and their normative inversions. Scatter plots a and b depict the result of closest mean classification of controls and individuals with Smith–Magenis syndrome. The arrows indicate the change in closest mean classification position of an individual and their normative inversion. In each case, the result of the normative inversion is to alter the original face or mid-line profile to be more like individuals in the affected group. Each scatter provides quantitative corroboration of the clinical evaluation of the shape change resulting from the inversion