Figure 2.

Efficacy of compounds upon ip administration. In two independent experiments, (A) and (B), compounds were administered at 40 mg/kg, ip, bid. Luminescence in mice was read upon luciferin injection on day 3 postinfection and prior to treatment (black bars) and on day 7 postinfection and after four days of treatment (gray bars). Each data point is an average of five mice; dpi-days postinfection. Posaconazole (Pos) served as a positive control. Percent inhibition for each compound is calculated relative to the untreated control on day 7 postinfection. *Values significantly different than vehicle-treated controls (p ≤ 0.05), except for LP10.