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Anti-T. cruzi efficacy of compounds in four-day mouse model of infection. (A) Dose–response in Kolliphor (KOL) versus HPβCD (CD) administration for compounds 5 (empty bars) and 12 (filled bars). Compound 5 in Kolliphor was more active than in HPβCD (p < 0.05) versus compound 12, which had comparable activity in both vehicles (P < 0.05). (B) Dose–response for Kolliphor administration of 5, 6, 7, and 12. Benznidazole (BNZ) served as a positive control.
