Figure 7.

Pyridine-based CYP51 inhibitors. (A) N-Indolyl-oxopyridinyl-4-aminopropanyl-based analogues. (B) Fenarimol analogues. Drug–heme van der Waals interactions are shown as resolved in the X-ray structures of the corresponding drug–target complexes (PDB ID codes are in parentheses). Heme is in gray van der Waals spheres; inhibitors colored by atom types with carbon highlighted in yellow are labeled by the small-molecule codes. The branching points in chemical structures are highlighted in green.