Table 2. Cytotoxicity of Compounds in Mouse Hepatocytes and Cardiomyocytes.
| hepatocytes |
cardiomyocytes |
|||
|---|---|---|---|---|
| compd | EC50 (μM) | selectivity index (SI)a | EC50 (μM) | selectivity index (SI) |
| 5 | 68.1 ± 7.2b | 3243 | 53.9 ± 8.1 | 2568 |
| 6 | 28.3 ± 4.1 | 166 | 22.2 ± 2.3 | 131 |
| 7 | 48.1 ± 12.5 | 616 | 23.3 ± 5.9 | 299 |
| 11 | >90 | >5000 | >90 | >5000 |
| 12 | >90 | >3000 | 83.2 ± 4.7 | 2869 |
a
Calculated as a ratio between the host cell and intracellular T. cruzi amastigote survival, both expressed as the corresponding EC50 values.
b
Each measurement performed in duplicate.