Table 4. TcCYP51 Amino Acid Point Contacts within 5 Å of the Inhibitors.
| amino acid residues | 1 (biaryl variant) | 12 (N-arylpiperazine variant) |
|---|---|---|
| invariant in CYP51 family | Y103, F110 | Y103, F110 |
| conserved across the phyla | F48, Y116, A291, T295, L356, M460 | F48, I72a, Y116, A291, T295, L356, M460 |
| substrate-specific | I105 | I105 |
| phylum-specific | M106, P210, V213, F290, | F55, I79, M106, P210, V213, F290 |
| more variable | F214, A287, M358, M360, V461 | I45, I70, V77, F214, A287, M358, M360, V461 |
a
Highlighted in bold are points of contact which do not overlap between two inhibitors.