Skip to main content
. 2014 Oct;70:117–126. doi: 10.1016/j.nbd.2014.06.012

Fig. 1.

Fig. 1

The cerebellum of adult Npc1−/− mice is reduced in size. (A) Gross morphological comparison of PN28 Npc1+/+ and Npc1−/− mouse cerebella (brackets). Cx: cortex; Cb: cerebellum; Bs: brain stem. (B) Sagittal sections of cerebellar vermis from PN28 Npc1+/+ and Npc1−/− mice, either untreated or treated with a single injection of HPBCD at PN7. Representative sections encompassing sagittal midline of vermis are shown in the figure. Superimposition of total vermis tracings indicates an overall size reduction in Npc1−/− mice compared to wild-type mice that was largely rescued by HPBCD treatment. (C) Histograms indicate total areas (mean ± SEM; 5–6 mice/group) measured on representative sections of Npc1+/+ (empty bar), Npc1−/− (full bar) and HPBCD-treated Npc1−/− mice (dashed bar). Asterisk indicates statistically significant differences (*p < 0.05). Scale bars indicate 2 mm (panel A) and 0.5 mm (panel B).