Fig. 6.

Potential side-effects of P2Y₁₂R antagonists. A, B. The effect of cangrelor (A) and PSB-0739 (B) treatment in accelerating rotarod test. A. Motor coordination was assessed 30 min after the injection of cangrelor (i.p.) and expressed in s, n = 10. B. PSB-0739 was administered intrathecally 15 min before testing at the dose (mg/kg) indicated on the abscissa (n = 9). C, D. The effect of cangrelor and PSB-0739 on ex vivo platelet aggregation induced by ADP (10 μM). The experimental animals were treated with saline (C: i.p., D: i.t.), cangrelor (C) and PSB-0739 (D). N = 4–9/group, **P < 0.01, Student t test. The results are expressed as percentage of maximal aggregation (%).