. 2014 Oct;70:162–178. doi: 10.1016/j.nbd.2014.06.011

Table 1.

Effect P2Y₁₂ receptor antagonists on mechanical hyperalgesia in inflammatory (CFA) and neuropathic (Seltzer) pain model as well as on acute thermal nociception.

Drug	Dose (mg/kg)	CFA	Seltzer	Hot plate test
Drug	Dose (mg/kg)	ΔPWT (g)	ΔPWT (g)	ΔPWT (°C)
PRE		40.66 ± 0.38	41.20 ± 0.37	n.d.
POST		20.12 ± 0.33***	18.48 ± 0.28***	n.d.
VEH i.p.		22.99 ± 2.16	17.13 ± 1.23	0.39 ± 0.32
SAL i.p.		19.5 ± 1.22	18.98 ± 1.71	− 0.71 ± 0.45
SAL i.t.		21.08 ± 1.92	17.20 ± 1.08	n.d.
MRS2395	0.03	23.47 ± 2.32	17.27 ± 1.48	− 0.36 ± 0.34
	0.1	19.58 ± 2.64	12.87 ± 0.7	1.33 ± 0.52
	0.3	22.65 ± 2.45	22.12 ± 0.76^##	1.51 ± 0.19**
	1	27.82 ± 2.63^#	23.3 ± 1.4^###	2.06 ± 0.40**
(±)Clopidogrel	0.3	n.d.	n.d.	0.60 ± 0.45
	1	21.72 ± 1.74	22.03 ± 0.77	1.05 ± 0.34*
	3	23.88 ± 1.94	24.01 ± 1.52^##	1.34 ± 0.39*
	10	28.43 ± 1.40^##	23.65 ± 1.33^#	1.31 ± 0.48*
	30	29.32 ± 1.53^##	28.10 ± 1.33^###	n.d.
	60	n.d.	27.04 ± 0.61^###	n.d.
Ticlopidine	3	24.58 ± 2.19^#	22.99 ± 1.63	0.23 ± 0.55
	10	28.15 ± 2.73^###	23.93 ± 0.85	0.65 ± 0.18*
	30	25.45 ± 2.18^#	28.17 ± 1.72^###	0.50 ± 0.19
	60	33.02 ± 1.45^###	n.d.	1.34 ± 0.46*
	100	32.33 ± 3.97^###	37.02 ± 3.04^###	2.69 ± 0.58**
PSB-0739 i.t.	0.01	20.51 ± 1.39	13.99 ± 1.20	1.84 ± 0.52*
	0.03	20.99 ± 1.75	18.23 ± 1.78	1.61 ± 0.37*
	0.1	25.00 ± 1.10^##	21.91 ± 1.80^###	1.47 ± 0.53*
	0.3	29.25 ± 2.53^###	20.53 ± 1.36^##	1.48 ± 0.27**
	1	n.d.	19.49 ± 1.06^#	n.d.
Cangrelor	0.1	29.25 ± 1.09^###	23.77 ± 1.38^##	0.96 ± 0.47
	0.3	26.86 ± 2.39	21.67 ± 1.22	0.74 ± 0.34
	0.6	27.07 ± 1.22^#	25.72 ± 1.31^###	0.27 ± 0.95
	1	32.63 ± 2.19^###	23.10 ± 2.03^#	1.48 ± 0.85
	3	n.d.	25.34 ± 1.91^###	n.d.
Reactive blue 2	0.1	21.50 ± 0.95	16.57 ± 0.38	n.d.
	0.3	19.17 ± 1.97	17.98 ± 1.21	0.35 ± 0.56
	0.6	26.68 ± 0.82^##	n.d.	n.d.
	1	26.00 ± 0.97^##	15.37 ± 2.00	0.58 ± 0.43
	3	18.22 ± 0.79	16.15 ± 0.93	− 0.73 ± 0.42
	60	n.d.	n.d.	0.0001 ± 0.43

In CFA experiments symbols indicate significant differences from the pre-CFA treatment (***P < 0.01) and post-CFA treatment PWT values (^##P < 0.01, ^###P < 0.001), respectively. One-way ANOVA followed by Neuman–Keuls post-hoc test, n = 6–12/group. In Seltzer experiments symbols indicate significant differences from the pre-CFA treatment (***P < 0.01) and from the postoperative values of saline (SAL) or vehicle (VEH) treated animals (^#P < 0.05, ^##P < 0.01, ^###P < 0.001). One-way ANOVA followed by Neuman–Keuls post-hoc test, n = 6–12/group. In hot plate tests asterisks indicate significant analgesic effect, compared to the pre-treatment values, *P < 0.05, **P < 0.01, paired t-test. n.d. = not determined.