Figure 4. Changes in k_Deg allow the reproduction of the Dl gradient in embryos derived from dl⁻/dl⁺ mothers.

Solid line and pink shadow, experimental quantification of Dl nuclear levels in the 30 most ventral nuclei (mean±SD, n = 5). Dotted lines indicate simulations with original values (light pink dots) for Dl nuclear import rates (k_i) and Cact degradation (k_Deg), and adjusted values (dark pink and black dots). The other parameters values used in the simulations are shown in the third column of Table 1. Gray shadow is a larger confidence interval (99%) due to the small sample size, and indicates that the slight deepening in the experimental gradient peak is not significant. V indicates ventral midline, y axis indicate normalized Dl levels, x axis indicate nuclei. See Table S5 for fit calculations.