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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Thromb Res. 2014 Jul 6;134(3):704–710. doi: 10.1016/j.thromres.2014.06.029

Table 1. Significant Canonical Pathways.

PLATELETS 0hr vs 24hr FC 1.5
Canonical Pathways −log10 p-value Genes
Intrinsic Prothrombin Activation 0.25 F11,F10,COL1A1,F12,SERPINC1,KLK3,F5,COL10A1,FGA,COL18A1,
THBD,F13B,F2,COL3A1
Extrinsic Prothrombin Activation 1.00 F10,F12,SERPINC1,F5,F7,TFPI,THBD,FGA,F3,F13B,F2
Glutamate Receptor Signaling 2.01 SLC17A8,GRM2,GRIN2A,SLC1A4,SLC17A6,GRM3,GRIA1,GRIN2D,
HOMER3,GRIA4,GRIK5,GRIN2C,HOMER1,GRM6,DLG4,SLC17A1,
GRIK2,GRIK1,GRIN1,GRIN2B,SLC1A6,CALML5,GRM8,GRM1,
GRIA2,GRIP1,SLC1A1,GRM4,GRIN3A,GRM5,GRM7,CALM1 (includes others),
GRIK4,SLC17A7,SLC1A2,GLUL, GRIA3
Insulin Receptor Signaling 0.32 PRKACB,RAPGEF1,SOCS3,ASIC2,MAPK1,BAD,SOS2,PDPK1,
LIPE,KRAS,PPP1R3A,PIK3R4,PPP1R14B,SCNN1A,MAP2K2,PPP1R7,
INS,TSC2,GSK3B,ATM,RPS6KB1,AKT2,EIF2B3,PPP1R11,
VAMP2,GYS2,SYNJ2,CBL,RHOQ,GAB1,PTPN11,IRS1,
PRKACG,PRKACA,EIF2B5,INSR,PIK3CA,PIK3R5,PPP1CB,STXBP4,
JAK2,OCRL,PTPRF,PDE3B,INPP5B,PIK3C3,SOS1,PTPN1,
FOXO3,RPTOR,AKT3,PIK3R2,NRAS,PIK3C2A,MAPK8,ACLY,
INPP5D,GRB10,PPP1R3D,RRAS2,PRKCI,SYNJ1,PRKA G2,PRKAR1A
MONOCYTES 0hr vs 24hr FC 1.5
Canonical Pathways −log10 p-value Genes
Wnt-B catenin Signaling 4.36 CDKN2A,WNT3,TGFBR3,SOX10,SOX12,CSNK1A1,WNT16,WNT6,
SOX13,RARG,CCND1,TCF7,PPM1J,WNT7B,RARA,PPM1L,
WNT4,WNT5B,TP53,AXIN2,APPL2,WNT9A,TCF3,CDH2,
CDH1,CDH12,CDH5,GNAO1,PPP2R2B,TGFB3,DKK4,FZD5,
LEF1,SOX8,SFRP1,DVL2,FZD10,MMP7,FRZB,SOX1,
PPP2R2A,LRP6,ACVR2B,HNF1A,WNT8B,H2 BFM,SOX17,
JUN,NLK,DKK3,RARB,TGFB2,AKT3,SFRP5,SOX14,
PPP2R2C,CTNNB1,ACVR1C,SOX5,SRC,SOX7,MDM2,SOX11,
FZD8,FZD4,SOX6,WNT10A,TLE4,CD44,NR5A2,BTRC,
SOX9,DVL3,DKK1,LRP1,TCF7L2,WNT5A,FZD7
Endothelin-1 Signaling 1.88 MAPK1,PLA2R1,SHC3,KRAS,MAPK13,PIK3R4,NOS3,LCAT,
MRAS,PLCB1,GNA13,PLCL1,GUCY1B3,PRKD1,PLA2G12A,PRKCQ,
GUCY1A3,ITPR2,MAPK4,MAPK12,PLD1,PIK3R3,PLA2G2D,GAB1,
ITPR3,GNAO1,GUCY1A2,GNAT2,PRKCH,ADCY10,GNAL,CASP5,
NOS1,GUCY2C,CASP4,GNA14,PRKCZ,SHC1,JUN,PIK3C3,
SOS1,PRKCE,ECE1,PNPLA3,NOS2,PLCD4,PRKCA,SRC,
ADCY2,GNAS,EDNRB,GNA12,PLA2G4C,ADCY6,PLCG1,PLA2G3,
PRKCG,GNAI2,PLCZ1,FOS,PLCB4,RRAS2,PLA2G4D,ADCY1,EDNRA,PTGS2,PRKCB
Intrinsic Prothrombin Activation 1.40 F11,KNG1,F10,COL1A1,F9,COL5A3,KLK3,F5,PROC,COL2A1,FGB,F GA,F13B,COL3A1