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. 2014 Aug 28;10(8):e1004468. doi: 10.1371/journal.pgen.1004468

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A–F) Tp63 and Dlx5 expression is normally detected in the limb ectoderm of control (A, B), Sp6−/−;Sp8+/− (C, D) and Sp6−/−;Sp8−/− (E, F) mutants although Dlx5 is downregulated. (G–H) Immunostaining for Tp63 (green) showing expression in the Sp6^−/−;Sp8^−/− double mutant limb bud similar to wild type littermate. All the panels show longitudinal sections of E10.5 forelimb buds.