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. 2014 Sep 1;25(17):2604–2619. doi: 10.1091/mbc.E14-02-0712

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© 2014 Barzik et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — Actin bundles in filopodia initiated by mDia2^M/A are not anchored in the lamellipodium actin network. Representative platinum-replica electron micrographs of actin cytoskeletons from MV^D7 cells. Filopodium F-actin bundles from control cells (A) and cells complemented with GFP-VASP (B) are deeply embedded in the actin network of the lamellipodium (arrowheads) and splay apart at the filopodium root. In contrast, filopodia actin bundles of cells producing GFP-mDia2^M/A (C) display poor connection to the underlying cortical cytoskeleton and do not have splayed roots (arrows), indicating that they may have formed via a different mechanism. Electron micrographs are representative images from at least three independent experiments. Scale bars, 0.5 μm.