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. 2014 Sep 1;25(17):2650–2659. doi: 10.1091/mbc.E14-01-0044

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© 2014 Du, Xia, Ning, Liu, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Bmi1 participates in hypoxia-induced renal fibrosis in vivo. (A) Immunohistochemical analysis for HIF-1α, Twist, and Bmi1 in the kidney tissue of UUO rats and sham-operated rats. Increased HIF-1α, Twist, and Bmi1 staining was observed in tissues of UUO rats. Original magnification, 200×. Top left insets, higher-magnification images (400×). (B) Western blot analyses indicating the induction of Bmi1 protein in fibrotic kidney. Samples from two representative animals were used at each time point. Left, representative blot from three independent experiments. Right, histogram showing the average volume density normalized to the loading control, β-actin (n = 3). *p < 0.01 compared with sham control.

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