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. 2014 Sep 1;25(17):2669–2676. doi: 10.1091/mbc.E14-04-0871

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© 2014 Mayhew and Mitra. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 5: — DNA looping provides transcriptional memory for activation of pseudohyphal growth. (A) Expression of FLO11 increases more rapidly in cells moved from rich to nitrogen-starved media when they had been pretreated with nitrogen-starved medium 4 h earlier. (B) Looping between the FLO11 promoter and terminator persists in pretreated cells, even after expression of FLO11 has returned to basal expression. (C) Strains with knockouts of nucleoporin protein Nup2 show decreased transcriptional memory for the same pretreatment experiment for FLO11. (D) Looping at FLO11 is inhibited in nitrogen-starved conditions in the mutant Nup2 strain. Error bars are shown as SD among three biological replicates.