Table 2. Statistics for mixed models.

	Overall Model		Effects
			Group		Time		Group*Time
	ChiSquare	p	F	p	F	p	F	p
Cold Pressor
All (mixed) Fig. 1	347	<0.0001	20	<0.0001	22	<0.0001	3	<0.0001
Female Fig. 4	140	<0.0001	4	0.05	7	<0.0001	2160	<0.0001
Male Fig. 4	201	<0.0001	17	0.0001	16	<0.0001	2	<0.0001
Hand Grip
All (mixed) Fig. 2	8192	<0.0001	3	0.1	17	<0.0001	4	<0.0001
Female Fig. 5	952	<0.0001	2	0.2	6	<0.0001	1	0.1
Male Fig. 5	6238	<0.0001	1	0.3	13	<0.0001	3	<0.0001
Valsalva
All (mixed) Fig. 3	7529	<0.0001	0	1	105	<0.0001	1	0.3
Female Fig. 6	3261	<0.0001	0	1	20	<0.0001	3	<0.0001
Male Fig. 6	4449	<0.0001	0.3	0.6	80	<0.0001	0.7	0.9

Chi Square statistics and p value are reported for repeated measures ANOVA, implemented as a mixed linear model with group, time and group by time as effects of interest (SAS proc mixed).