Table 3. Fatty acid amide hydrolase inhibitor JNJ-5003 prevents the effects of chronic stress on anxiety-like behavior in the elevated plus maze.<.

br>Three weeks exposure of restraint stress (6 h/day) to rats fed normal rat chow (control) increased indices of anxiety in the elevated plus maze (time spent in the open arm and latency to enter the open arm). The FAAH inhibitor JNJ-5003 was incorporated into the diet and which was fed to rats for the twenty-one day duration of the chronic stress regimen, resulting in an estimated dose of 50 mg/kg/day. Administration of JNJ-5003 during chronic stress mitigated the increased indices of anxiety seen in the rats fed control chow.

	Control	Chronic Stress
Time Spent in the Open Arms (s)
Control	112.6 +/− 10.1	55.3 +/− 7.5*
JNJ-5003	106.6 +/− 11.4	93.4 +/− 10.8
Latency to Enter the Open Arms (s)
Control	9.9 +/− 2.6	27.4 +/− 6.3✦
JNJ-5003	12.1 +/− 2.9	18.8 +/− 2.4

Data are presented as mean values +/− SEM (n = 7–8 / condition).

^*denotes significant differences (p < 0.05) between chronically stressed rats fed normal chow and all other treatment conditions.

^✦denotes significant difference (p < 0.05) between chronically stress rats fed normal chow and unstressed rats fed normal chow.