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. 2014 Aug 28;9(8):e105372. doi: 10.1371/journal.pone.0105372

Figure 6. Genetic inhibition of Notch signaling reduces hypoxia-mediated cellular invasion.

Figure 6

A, The protein levels of HIF-1α and CBF1 were determined by Western blot in 92.1 cells infected with CBF1 or scramble shRNAs and exposed to normoxia or hypoxia for 24 hours; β-Actin was used as loading control. B, Growth rate was determined by MTS assay in 92.1 cells infected with CBF1 or scramble shRNAs and exposed to normoxia or hypoxia for 2, 4, 6 days (*p = 0.01; **p = 0.001; ***p<0.0001). C, Transwell invasion assay was performed in 92.1 cells infected with CBF1 or scramble shRNAs and exposed for 24 hours to normoxia or hypoxia (***p<0.0001).

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