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. 2014 Aug 28;9(8):e105652. doi: 10.1371/journal.pone.0105652

Figure 1. Analysis of O. tsutsugamushi Ank proteins.

Figure 1

(A) Schematic representation of nine Ank proteins selected from the master genes (Ank1A–F) of 6 subgroups and single-copy genes (Ank1U4, 5, and 9) containing a PRNAC domain in their C-terminus. Each Ank domain predicted by SMART (Simple Modular Architecture Research Tool, http://smart.embl-heidelberg.de/) is shown as a white box at its relative amino acid position within the full length Ank protein. Predicted PRANC domains are indicated by dark gray boxes and signal peptides by a light gray box. (B) Alignment of the amino acid sequences of the C-terminal PRNAC domains of seven Ank proteins. Residues shared by the majority of the seven sequences are shaded. The bottom portion of the figure shows consensus sequences of the F-box (F-box CON) [48] together with F-box–like domains of poxviruses (POX CON) and O. tsutsugamushi (OT CON), with lower case letters representing variant positions as follows: i representing I, L or V, and d representing D or E. A dot (.) indicates non-conserved positions.