Table 3. Subgroup analysis based on different FIB-4 index cutoff values.

Thresholds	Number ofstudies	Summary estimates(95% CI)			Likelihood ratio (95%CI)		AUHSROC(95% CI)
		Sensitivity	Specificity	DOR	PLR	NLR
Significant fibrosis
0.8–1.085	5	0.73 (0.68–0.77)	0.62 (0.56–0.67)	4 (3–6)	1.9 (1.6–2.2)	0.44 (0.36–0.54)	0.73 (0.69–0.77)
1.45–1.62	6	0.65 (0.56–0.73)	0.77 (0.7–0.83)	6.24 (4.06–9.61)	2.83 (2.16–3.71)	0.45 (0.36–0.57)	0.78 (0.74–0.81)
3.25	3	0.18 (0.13–0.24)	0.98 (0.95–0.99)	7.53 (3.06–18.54)	6.04 (2.61–13.96)	0.85 (0.76–0.95)	0.61 (0.57–0.65)
Severe fibrosis
1.45–1.65	4	0.68 (0.6–0.75)	0.75 (0.69–0.81)	6.44 (4.44–9.35)	2.75 (2.21–3.43)	0.42 (0.34–0.53)	0.77 (0.73–0.80)
Cirrhosis
1.6–2.29	7	0.82 (0.75–0.88)	0.77 (0.71–0.82)	15.55 (8.69–27.80)	3.59 (2.73–4.74)	0.23 (0.16–0.33)	0.87 (0.84–0.90)
2.9–3.6	3	0.42 (0.36–0.48)	0.96 (0.95–0.97)	46.28 (18.3–117.04)	13.38 (9.24–19.37)	0.3 (0.06–0.45)	0.96 (0.92–1.00)

95% CI: 95% confidence interval. DOR: diagnostic odds ratio. PLR: positive likelihood ratio; NLR: negative likelihood ratio. AUHSROC: area under the hierarchical summary receiver operating characteristic curve.