Table 2. Univariable and Multivariable Analysis for Unfavorable Functional Outcome at 3 Months (mRS, 3–6).

	Unfavorable outcome(n = 2626)	Favorable outcome(n = 4449)	Univariable analysis		Multivariable analysis
			OR (95% CI)	P	*aOR (95% CI)	P
Age, year	72.8 (±11.6)	64.4 (±12.8)	1.06 (1.06–1.07)	<0.001	1.05 (1.04–1.06)	<0.001
Male	1281 (48.8)	2865 (64.4)	0.53 (0.48–0.58)	<0.001	0.68 (0.55–0.85)	0.001
Risk factor (%)
Previous stroke	824 (31.4)	694 (15.6)	2.47 (2.20–2.78)	<0.001	2.14 (1.68–2.73)	<0.001
Hypertension	1941 (73.9)	2985 (67.1)	1.39 (1.25–1.55)	<0.001	0.93 (0.74–1.18)	0.539
Diabetes	989 (37.7)	1390 (31.2)	1.33 (1.20–1.47)	<0.001	1.12 (0.90–1.40)	0.311
Hyperlipidemia	850 (32.4)	1484 (33.4)	0.96 (0.86–1.06)	0.394
Current Smoking	511 (19.5)	1364 (30.7)	0.55 (0.49–0.61)	<0.001	1.10 (0.84–1.44)	0.496
TIA presentation andStroke subtype, n (%)
TIA presentation	3 (0.1)	32 (0.7)	0.35 (0.11–1.15)	0.084	0.01 (1.00–1.00)	1.000
LAA	1023 (39.0)	1585 (35.6)	2.41 (2.07–2.81)	<0.001	1.74 (1.30–2.32)	<0.001
SVO	288 (11.0)	1077 (24.2)	1.0 (referent)	-	1.0 (referent)	-
CE	685 (26.1)	731 (16.4)	3.50 (2.97–4.14)	<0.001	1.02 (0.72–1.45)	0.898
SOE	59 (2.2)	117 (2.6)	1.89 (1.34–2.65)	<0.001	4.37 (2.33–8.21)	<0.001
SUE	568 (21.6)	907 (20.4)	2.34 (1.98–2.77)	<0.001	1.18 (0.84–1.64)	0.345
NIHSS score at admission
Mean (±SD)	9.3 (±6.8)	3.1 (±3.3)	1.31 (1.29–1.33)	<0001	1.29 (1.25–1.32)	<0.001
Median (IQR)	7 (10)	2 (3)		<0.001
Prehospital delay (hour)	7.7 (25.2)	9.1 (±27.6)	1.00 (1.00–1.00)	0.005	1.00 (1.00–1.00)	0.935
Onset to Needle time (min)	115 (67)	115 (62)		0.906
Door to Needle time (min)	45 (24)	45 (22)		0.366
IV rtPA	282 (29.2)	324 (23.4)	1.35 (1.12–1.63)	0.002	0.46 (0.34–0.61)	<0.001
Off-hour (vs. Work-hour)	1291 (49.2)	2182 (49.0)	1.01 (0.91–1.11)	0.924	0.89 (0.72–1.09)	0.262

Abbreviations are presented in the previous table.

All the 7075 patients were included in the multivariable analysis.

*aOR: adjusted odds ratio.