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. 2014 Aug 28;9(8):e105665. doi: 10.1371/journal.pone.0105665

Figure 4. Induced elevation of sCD14 is associated with triple therapy outcome.

Figure 4

(A) Differences in the induction of sCD14 between sustained virological response (SVR) and no sustained response (NSR) patients whom undergo dual therapy (SVR n = 33, NSR n = 19). (B) Differences in the induction of IL-18 between SVR and NSR patients whom undergo dual therapy (SVR n = 33, NSR n = 19). (C) Differences in the induction of sCD14 between SVR and NSR patients whom undergo triple therapy (SVR n = 36, NSR n = 36, unpaired T test with Welch’s correction P = 0.0435). (D) Differences in the induction of IL-18 between SVR and NSR patients whom undergo triple therapy. *P≤0.05. Patients in the triple therapy cohort were ordered with those with the highest levels of sCD14 elevation in quartile 1 (Q1) to the lowest in Q4 and number of patients with a SVR or NSR in each quartile was assessed. (E) Number of SVR and NSR patients in each sCD14 quartile (n = 72). (F) Number of SVR and NSR patients in each IL-18 quartile (n = 72). P values shown represent Chi-squared test for trend.