Table 2. Cortical regions with a significant increase in 7 Tesla T2* in CADASIL patients compared to age and sex matched healthy subjects from the GLM analysis.

	Cortical area	p-value1	Cluster size2 (mm2)	Talairach coordinates			ROI T2* signal				ROI cortical thickness (mm)
				x	y	z	CADASIL		Controls		CADASIL		Controls		p-value3
							mean	sd	mean	sd	mean	sd	mean	sd
Left
	Anterior cingulate gyrus and sulcus	7.1×10−6	184.54	−8.2	44.9	1.8	0.85	0.08	0.77	0.14	2.42	0.23	2.40	0.21	0.54
	Paracentral lobule and sulcus	9.5×10−6	321.24	−8.8	−39	59.1	0.78	0.08	0.66	0.14	2.30	0.16	2.41	0.19	0.07
	Fronto-marginal gyrus and sulcus	2.8×10−5	58.24	−23.6	51.6	−1.9	0.84	0.08	0.71	0.15	2.46	0.23	2.40	0.23	0.26
	Superior occipital gyrus	3.1×10−5	597.53	−22.6	−78.7	38	0.81	0.08	0.70	0.14	2.39	0.22	2.41	0.18	0.99
	Angular gyrus	6.2×10−5	681.73	−40.8	−73	36	0.83	0.08	0.73	0.15	2.38	0.17	2.42	0.12	0.44
	Superior parietal lobule	1.3×10−4	374.21	−14.3	−74.6	46	0.79	0.08	0.69	0.13	2.41	0.17	2.40	0.15	0.73
	Superior parietal lobule	2.5×10−4	320.59	−22.1	−60.5	53.8	0.79	0.07	0.69	0.14	2.35	0.25	2.38	0.21	0.86
	Superior frontal gyrus	3.8×10−4	102.05	−4.7	21.2	58.6	0.69	0.08	0.56	0.14	2.38	0.15	2.42	0.13	0.43
	Superior frontal gyrus	4.5×10−4	106.22	−17.6	46.5	35.6	0.76	0.07	0.64	0.12	2.35	0.23	2.42	0.16	0.48
Right
	Intraparietal sulcus	4.3×10−5	3112.85	21.3	−60.4	44.9	0.80	0.07	0.71	0.14	2.45	0.20	2.40	0.16	0.43
	Superior frontal gyrus	5.9×10−5	488.89	4.4	27.2	46.2	0.69	0.08	0.57	0.14	2.50	0.34	2.50	0.32	0.92
	Paracentral lobule and sulcus	7.8×10−5	412.82	11.6	−36.9	60.2	0.74	0.09	0.62	0.14	2.41	0.18	2.39	0.22	0.62
	Superior frontal gyrus	3.0×10−4	1165.26	17.5	55.5	20.5	0.80	0.06	0.70	0.14	2.40	0.19	2.47	0.19	0.27
	Intraparietal sulcus	3.2×10−4	286.68	36.5	−42.4	48.6	0.78	0.06	0.70	0.13	2.39	0.25	2.40	0.23	0.88
	Postcentral gyrus	3.3×10−4	139.72	39.5	−22.5	57.2	0.74	0.08	0.64	0.15	2.44	0.26	2.39	0.16	0.35
	Superior occipital gyrus	5.8×10−4	233.97	11	−84.7	34.9	0.77	0.07	0.66	0.14	2.39	0.30	2.34	0.23	0.37
	Angular gyrus	6.3×10−4	109.8	54.8	−51.8	32.1	0.83	0.07	0.75	0.15	2.41	0.17	2.41	0.21	0.68
	Middle occipital gyrus	6.7×10−4	198.66	45.5	−76.8	12.2	0.78	0.07	0.70	0.14	2.41	0.31	2.33	0.26	0.36
	Middle frontal sulcus	7.0×10−4	73.3	29.7	48	3.7	0.80	0.09	0.70	0.15	2.39	0.29	2.40	0.25	0.82
	Middle frontal gyrus	9.4×10−4	52.24	39.1	52.8	8.6	0.79	0.05	0.72	0.15	2.50	0.18	2.40	0.20	0.08
	Postcentral sulcus	1.2×10−3	58.37	43.5	−33.5	42	0.80	0.08	0.74	0.14	2.31	0.29	2.30	0.28	0.83
	Transverse temporal sulcus	1.3×10−3	70.34	57.4	−11.8	4.2	0.79	0.07	0.67	0.16	2.25	0.35	2.36	0.35	0.28
Global							0.73	0.07	0.68	0.13	2.59	0.14	2.57	0.09	0.49

Cortical thickness measurements in these regions of interest (ROI) are also reported.

¹max uncorrected p-value in the cluster, p_right >0.003, p_left >0.001 (False discovery rate = 0.05);

²cluster area >50 mm²;

³adjusted for age, gender and level of education (p-value obtained at the cluster level).