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. 2014 Aug 28;10(8):e1004337. doi: 10.1371/journal.ppat.1004337

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Sequence alignments of the isolated NHP VH1.23-using MAbs. The framework regions (FR) are boxed in gray and the amino acid differences compared to the germline VH1.23 sequence are highlighted in yellow. Depicted below the MAb sequences is the newly discovered VH1.23*02 germline allele. (B) Alignments of the GE356 heavy and light chain sequences with the assigned germline sequences. (C) Summary of the genetic characteristics of the VH1.23 vaccine-induced MAbs.