Table 2.
Age- and multiple-adjusted* estimates of association of brain levels of α-Tocopherol and γ-Tocopherol with measures of neuropathology based on linear regression models of 113 deceased participants of the Memory and Aging Project
| α-TOCOPHEROL TERTILES | ||||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| Log Median pmoles/mg protein | 1.8 | 2.3 | 2.6 | LINEAR TERM |
| MODEL | β (p-value) | β (p-value) | β (p-value) | β (p-value) |
| Amyloid Load | ||||
| Age-adjusted | 1.0 | −0.74 (.85) | −0.31 (.94) | −0.006 (.99) |
| Multiple-adjusted | 1.0 (referent) | −0.35 (.38) | −0.21 (.60) | −0.27 (.56) |
| Neurofibrillary Tangle Severity (Braak Score) | ||||
| Age-adjusted | 1.0 (referent) | −0.27 (.34) | −0.40 (.17) | −0.36 (.45) |
| Multiple-adjusted | 1.0 (referent) | −0.50 (.08) | −.51 (.08) | −0.55 (.12) |
| γ-TOCOPHEROL TERTILES | ||||
| 1 | 2 | 3 | ||
| Log Median pmoles/mg protein | 1.6 | 1.8 | 2.1 | LINEAR TERM |
| MODEL | β (p-value) | β (p-value) | β (p-value) | β (p-value) |
| Amyloid Load | ||||
| Age-adjusted | 1.0 (referent) | 0.11 (.77) | −0.59 (.14) | −1.14 (.09) |
| Multiple-adjusted | 1.0 (referent) | −0.03 (.94) | −1.06 (.007) | −2.10 (.002) |
| Neurofibrillary Tangle Severity (Braak Score) | ||||
| Age-adjusted | 1.0 (referent) | −0.13 (.66) | −0.34 (.24) | −0.87 (.09) |
| Multiple-adjusted | 1.0 (referent) | −0.26 (.36) | −0.60 (.04) | −1.16 (.02) |
*
Multiple-adjusted models adjusted for age at death (years), sex, education (years), APOE-ε4 (any ε4 versus none) and post-mortem autopsy time (hours)