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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Arthritis Rheumatol. 2014 Jun;66(6):1482–1491. doi: 10.1002/art.38393

Figure 3.

Figure 3

Normal plasma cell numbers but reduced total serum IgG in PAD4−/− mice with TNFα-induced arthritis. Bone marrow from TNF+PAD4+/+ and TNF+PAD4−/− littermates at age 5 months was stained with B220 and CD138 for flow cytometry. A, Shown are a representative dot plot with plasma cells in the boxed area (representative of all mice from 7 experiments) (left) and plasma cell percentages (n = 7 littermate pairs) (right). B and C, Enzyme-linked immunosorbent assay was used to measure IgG levels in sera from TNF+PAD4+/+ and TNF+PAD4−/− littermates at age 5 months (n = 8 littermate pairs) (B) and PAD4+/+ and PAD4−/− littermates at age 3 months (n = 4 littermate pairs) (C). Values are the mean ± SEM. * = P < 0.05 by unpaired t-test. See Figure 2 for definitions.