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. Author manuscript; available in PMC: 2014 Aug 29.
Published in final edited form as: J Immunol. 2013 Feb 25;190(7):3068–3078. doi: 10.4049/jimmunol.1202441

FIGURE 6. Titers and specificities of Abs raised by immunization of rabbits with rBet v 1 and PreS fusion proteins.

FIGURE 6

(A) Bet v 1–specific IgG levels (y-axes: OD values) for different serum dilutions of rabbits that were immunized with Ags (2PA-PreS, 2PB-PreS, 4PA-PreS, 2PAPB-PreS, rBet v 1) adsorbed to aluminum hydroxide (Alum) (left panel) or CFA (right panel). (B) IgG levels (y-axis: mean OD values) of the anti-sera shown in (A) for Bet v 1 and for six Bet v 1–derived peptides (P1′–P6′). (C) Sequence alignment of Bet v 1 and Bet v 1–homologous allergens from alder (Aln g 1), hazel (Cor a 1), and apple (Mal d 1). Identical amino acids are indicated by dots, and gaps are represented by dashes. Numbers of amino acids and percentage of sequence identity with Bet v 1 are shown to the right. Peptides A (PA: light gray box) and B (PB: dark gray box) are indicated. (D) IgG levels (y-axis: mean OD values) of the preimmune and immune sera shown in (A) for Bet v 1, Aln g 1, Cor a 1, and Mal d 1 (x-axis).

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