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. Author manuscript; available in PMC: 2014 Aug 29.
Published in final edited form as: Curr Opin Immunol. 2010 Oct;22(5):669–681. doi: 10.1016/j.coi.2010.08.018

Figure 2.

Figure 2

Factors affecting alloantibody production - Alloantibodies are produced by plasma cells. Alloantibody titres will therefore by determined by: (a) The provision of plasma cell survival factors by stromal cells within bone marrow niches, for example cytokines such as IL-6 and BAFF. (b) The rate of alloantibody production by plasma cells, which may be increased by TLR stimulation and blocked by CCL2. (c) The provision of additional, ectopic plasma cell niches within rejecting, inflamed allograft. (d) Factors affecting memory B cell activation.