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. 2013 Jan 10;14(3):409–421. doi: 10.1093/biostatistics/kxs057

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Fig. 1. — Contour plots of the required total sample size with the hazard ratios of time-to-events of virologic and regimen failures, and correlation for the three copulas. The sample size was calculated to detect the joint reduction for both time-to-event outcomes with the overall power of 0.90 at the one-sided significance level of 0.0125, where ρ=ρ⁽¹⁾=ρ⁽²⁾=0.0, 0.3, 0.5, and 0.8; , and ; τ_a=0, and τ_f=96; a⁽¹⁾=0.5.

Inline graphic — Contour plots of the required total sample size with the hazard ratios of time-to-events of virologic and regimen failures, and correlation for the three copulas. The sample size was calculated to detect the joint reduction for both time-to-event outcomes with the overall power of 0.90 at the one-sided significance level of 0.0125, where ρ=ρ⁽¹⁾=ρ⁽²⁾=0.0, 0.3, 0.5, and 0.8; , and ; τ_a=0, and τ_f=96; a⁽¹⁾=0.5.