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. 2014 Aug 29;5:202. doi: 10.3389/fphar.2014.00202

Figure 2.

Figure 2

Schematic representation of the predicted topology of Cdr1p. Cdr1p is predicted to have two transmembrane domains (TMD1 and TMD2) and two NBDs, (N- and C-terminal NBDs) organized in reverse (NBD-TMS6)2 topology. The amino and carboxyl terminals of protein are indicated. Each TMD consists of six TMSs, which are numbered 1–6 in TMD1 and 7–12 in TMD2. Six extracellular loops (ECL1-6) and four intracellular loops (ICL1-4) are indicated.