Table 1.
ABC transporters of Candida albicans.
| Subfamilya | ORF names | Gene name | Sizeb | Location | Topologyc | Function | References |
|---|---|---|---|---|---|---|---|
| PDR | CaO19.6000 | CaCDR1 | 1501 | PM | (NBD-TMS6)2 | Drug effIux, phospholipid translocation | Prasad et al., 1995 |
| CaO19.5958 | CaCDR2 | 1499 | PM | (NBD-TMS6)2 | Drug effIux, phospholipid translocation | Sanglard et al., 1997 | |
| CaOI9.1312 | CaCDR3 | 1501 | PM | (NBD-TMS6)2 | Opaque-phase specific transporter, phospholipid translocation | Balan et al., 1997; Smriti et al., 2002 | |
| CaO19.5079 | CaCDR4 | 1490 | ND | (NBD-TMS6)2 | Phospholipid translocation | Franz et al., 1998 | |
| CaO19.918 | CaCDR99 | 683 | ND | NBD-TMS6 | Drug efflux pump | Gaur et al., 2005 | |
| CaO19.919 | 819 | ND | NBD-TMS6 | ND | Gaur et al., 2005 | ||
| CaO19.5759 | 1493 | ND | (NBD-TMS6)2 | ND | Gaur et al., 2005 | ||
| CaO19.4531 | 1245 | ND | (NBD-TMS6)2 | ND | Gaur et al., 2005 | ||
| CaO19.3120 | 584 | ND | NBD-TMS6 | ND | Gaur et al., 2005 | ||
| CaO19.459 | 719 | ND | TMS1-NBD-TMS7 | ND | Gaur et al., 2005 | ||
| MDR | CaO19.7440 | CaHST6 | 1328 | ND | (TMS6-NBD)2 | Transport of α-factor, drugs | Raymond et al., 1998 |
| CaO19.2615 | CaMDL1 | 659 | ND | TMS6-NBD | ND | Gaur et al., 2005 | |
| CaOI9.13043 | 726 | ND | TMS6-NBD | ND | Gaur et al., 2005 | ||
| CaOI9.1077 | 730 | ND | TMS6-NBD | ND | Gaur et al., 2005 | ||
| MRP/CFTR | CaO19.6478 | CaYOR1 | 711 | PM | TMS6-NBD | Drug efflux pump | Gaur et al., 2005 |
| CaO19.1783 | CaYCF1 | 1512 | Vacoule | (TMS6-NBD)2 | Drug efflux pump | Gaur et al., 2005 | |
| CaO19.5100 | CaMLT1 | 1544 | Vacoule | (TMS6-NBD)2 | Transport involved in virulence | Theiss et al., 2002 | |
| CaO19.6382 | 1254 | ND | (TMS6-NBD)2 | ND | Gaur et al., 2005 | ||
| CaO19.1784 | 763 | ND | TMS6-NBD | ND | Gaur et al., 2005 | ||
| ALDp | CaO19.7500 | 652 | ND | TMS6-NBD | ND | Gaur et al., 2005 | |
| CaO19.5255 | 615 | ND | TMS6-NBD | ND | Gaur et al., 2005 | ||
| EF3 | CaO19.6060 | 751 | ND | NBD-NBD | ND | Gaur et al., 2005 | |
| CaO19.2183 | 585 | ND | NBD-NBD | ND | Gaur et al., 2005 | ||
| CaO19.7332 | CaELF1 | 1097 | ND | NBD-NBD | M-RNA export factor | Sturtevant et al., 1998 | |
| CaO19.4152 | CaCEF3 | 978 | ND | NBD-NBD | ND | Myers et al., 1992 | |
| RLI | CaO19.3034 | 602 | ND | NBD-NBD | ND | Gaur et al., 2005 | |
| Others | CaO19.5029 | 545 | ND | NBD-NBD | ND | Gaur et al., 2005 | |
| CaO19.388 | 276 | ND | NBD | ND | Gaur et al., 2005 |
a
subfamily based on sequence similarity with human ABC transporters.
b
Number of amino acid residues.
c
NBD, nucleotide-binding domains; TMS, transmembrane segments.
ND, signifies not defined.