Table 1. Cardiac phenotype of Bellomo and Aase Vegf-b-/- mice.
| Phenotype | Parameter | Aase WT | Aase Vegf-b-/- | Bellomo WT | Bellomo Vegf-b-/- |
|---|---|---|---|---|---|
| Heart function | EF (%) | 56.18 ± 9.45 | 65.57 ± 13.72 | 62.75 ± 6.09 | 66.77 ± 9.90 |
| FS (%) | 29.31 ± 5.94 | 36.57 ± 9.86 | 33.66 ± 4.29 | 36.91 ± 7.13 | |
| Heart size | LVAW; d (mm) | 0.84 ± 0.14 | 0.93 ± 0.15 | 0.95 ± 0.10 | 0.92 ± 0.13 |
| LVAW; s (mm) | 1.21 ± 0.14 | 1.37 ± 0.33 | 1.38 ± 0.14 | 1.45 ± 0.21 | |
| LVID; d (mm) | 4.24 ± 0.33 | 3.95 ± 0.14 | 4.05 ± 0.16 | 3.94 ± 0.17 | |
| LVID; s (mm) | 3.01 ± 0.48 | 2.50 ± 0.36 | 2.69 ± 0.23 | 2.49 ± 0.38 | |
| LVPW; d (mm) | 0.72 ± 0.12 | 0.80 ± 0.14 | 0.77 ± 0.11 | 0.79 ± 0.10 | |
| LVPW; s (mm) | 1.08 ± 0.16 | 1.20 ± 0.28 | 1.20 ± 0.17 | 1.23 ± 0.118 | |
| LV Vol; d (µl) | 80.88 ± 14.52 | 67.90 ± 5.67 | 72.24 ± 6.70 | 67.73 ± 6.69 | |
| LV Vol; s (µl) | 36.40 ± 14.31 | 22.92 ± 8.64 | 27.05 ± 5.60 | 22.99 ± 9.27 | |
| LV mass | 124.92 ± 23.39 | 129.88 ± 15.01 | 132.93 ± 12.09 | 125.94 ± 22.15 | |
| ECG | PQ interval (ms) | 43.97 ± 2.41 | 42.59 ± 3.65 | 43.80 ± 1.25 | 43.30 ± 1.12 |
| QRS interval (ms) | 10.41 ± 0.48 | 10.06 ± 0.20 | 10.43 ± 0.46 | 10.86 ± 0.27 | |
| QT interval (ms) | 37.50 ± 3.52 | 41.11 ± 2.63 | 41.25 ± 2.36 | 39.93 ± 0.97 | |
| P amplitude (mV) | 1.250 ± 0.25 | 0.8376 ± 0.24 | 1.221 ± 0.12 | 1.261 ± 0.12 | |
| R amplitude (mV) | 10.11 ± 0.59 | 10.43 ± 0.75 | 9.495 ± 0.74 | 10.08 ± 0.45 | |
| Heart rate (bpm) | 366.0 ± 32.17 | 400.3 ± 20.08 | 439.1 ± 18.27 | 441.6 ± 19.11 |
Heart function determined by ejection fraction (EF) and fractional shortening (FS). Heart size in diastole (d) and systole (s) represented by left ventricular anterior wall (LVAW) thickness, left ventricular internal diameter (LVID), left ventricular posterior wall (LVPW) thickness, left ventricle (LV) volume and LV mass in Aase and Bellomo VEGF-B-/- and littermate control mice. ECG recordings are shown as PQ, QRS and QT interval, heart rate in beats per minute (bpm) and amplitudes of P and R peak. Results are expressed as mean ± S.E.M. n = 4–9.