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. 2014 Aug 29;4:6234. doi: 10.1038/srep06234

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Histological changes were determined by hematoxylin and eosin staining. Water group showing normal histology of mice colon (a). Mucosal injury produced after DSS administration with distortion of crypts (b). DSS + 20 mg/kg RR-ARFs samples showing a reduction in the morphological alteration associated to DSS treatment (c).