Table 2. 18 exosomal lung cancer biomarker candidates.
| m/z | z | Protein Descriptions | UniProtKB entry | Protein Accessions | Sequence | XCorr |
|---|---|---|---|---|---|---|
| 713.401 | 2 | Brain-specific angiogenesis inhibitor 1-associated protein 2 | BAIP2 | Q9UQB8 | EGDLITLLVPEAR | 3.22 |
| 579.285 | 2 | Copine-1 | CPNE1 | Q99829 | SDPFLEFFR | 2.67 |
| 507.583 | 3 | Fibrinogen alpha chain | FIBA | P02671 | GLIDEVNQDFTNR | 4.54 |
| 1047.638 | 2 | Complement C5 | CO5 | P01031 | LNLVATPLFLKPGIPYPIK | 3.79 |
| 1011.136 | 3 | Prolow-density lipoprotein receptor-related protein 1 | CD91/LRP1 | Q07954 | DGIHNVEGVAVDWMGDNLYWTDDGPK | 4.57 |
| 953.123 | 3 | Mannan-binding lectin serine protease 1 | MASP1 | P48740 | ETTDTEQTPGQEVVLSPGSFMSITFR | 5.28 |
| 1027.069 | 2 | Apolipoprotein B-100 | APOB | P04114 | ILGEELGFASLHDLQLLGK | 5.58 |
| 1100.068 | 2 | Complement component C8 alpha chain | CO8A | P07357 | YNPVVIDFEMQPIHEVLR | 5.22 |
| 619.324 | 2 | Plasminogen | PLMN | P00747 | FVTWIEGVMR | 3.31 |
| 481.584 | 3 | Basement membrane-specific heparan sulfate proteoglycan core protein | PGBM | P98160 | IAHVELADAGQYR | 3.52 |
| 670.872 | 2 | Myeloperoxidase | PERM | P05164 | IGLDLPALNMQR | 3.30 |
| 1441.657 | 2 | IgGFc-binding protein | FCGBP | Q9Y6R7 | VPSSYAEALCGLCGNFNGDPADDLALR | 4.49 |
| 512.332 | 2 | Integrin alpha-IIb | ITA2B | P08514 | IVLLDVPVR | 3.21 |
| 1020.122 | 3 | Ig kappa chain V-III region HIC | KV313 | P18136 | LEPEDFAVYYCQQYGSSPWTFGQGTK | 4.62 |
| 742.352 | 2 | Plasma protease C1 inhibitor | IC1 | P05155 | VTTSQDMLSIMEK | 2.65 |
| 542.811 | 2 | Alpha-2-macroglobulin | A2MG | P01023 | GHFSISIPVK | 3.09 |
| 1141.520 | 3 | Bone marrow stromal antigen 2 | CD317/BST2 | Q10589 | GFQDVEAQAATCNHTVMALMASLDAEKAQGQK | 3.11 |
| 727.377 | 2 | Hyaluronan-binding protein 2 | HABP2 | Q14520 | LKPVDGHcALESK | 2.95 |
NOTE: m/z, mass/charge; z, charge; XCorr, cross-correlation score from Sequest database search.