Table 2.
Results of univariate and multivariate analyses.
| Mucositis Grade
|
Odds ratio | 95% Confidence interval | P | ||
|---|---|---|---|---|---|
| 1–2 N (%) |
3–4 N (%) |
||||
| Univariate analysis | |||||
| All patients | 33 (43) | 44 (57) | |||
| HPV-positive | 21 (34) | 41 (66) | 6.86 | 1.7–27.1 | 0.0061 |
| HPV-negative | 12 (80) | 36 (20) | |||
| Non-smokers | 15 (36) | 27 (64) | |||
| Smokers | 18 (60) | 12 (40) | 2.70 | 1.03–7.09 | 0.044 |
| HPV-positive patients | |||||
| Non-smokers | 12 (31.6) | 26 (68.4) | |||
| Smokers | 9 (47) | 10 (53) | 1.95 | 0.63–6.04 | 0.24 |
| Multivariate analysis: odds of grade 3–4 mucositis | |||||
| Nodal stage (N0–N2a vs. N2b-N3) | 0.27 | 0.06–1.30 | 0.100 | ||
| IMRT (yes vs. no) | 0.20 | 0.04–0.87 | 0.032 | ||
| Max oropharyngeal radiotherapy dose | 1.08 | 1.00–1.15 | 0.032 | ||
| Smoking (Smokers vs. non-smokers) | 0.52 | 0.16–1.70 | 0.278 | ||
| HPV (Positive vs. negative) | 5.30 | 1.15–24.4 | 0.032 | ||
CI = confidence interval; HPV = human papillomavirus; N = number; N = node.