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. 2014 Aug 29;5:272. doi: 10.3389/fgene.2014.00272

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Copyright © 2014 Suzuki, Frick, Parks, Trask, Butz, Steffy, Chan, Scoville, Healy, Benton, McQuaid, Thomas and Wiltshire.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic region associated with rotenone cytotoxicity. (A) GWA Manhattan plot for cell loss after 72 h of rotenone treatment. The region with the highest -log p-value that was selected for further analysis is indicated by the arrow. (B) Detail of the region in chromosome X annotated with the candidate genes. (C) Haplotype structure of the inbred mouse strains in the region. The black box indicates the 3-SNP haplotype with the best SNPster association score, which includes the Cybb gene (chromosome X 9,012,380–9,046,450).