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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Immunol. 2014 Aug 10;15(9):875–883. doi: 10.1038/ni.2958

Figure 6.

Figure 6

Ptpn22 limits the pro-inflammatory capacity of HP-induced memory T cells. WT and Ptpn22−/− (KO) HP-induced (a-c) or LmOva-induced (d-f) Rag1−/− OT-1 memory T cells were recovered from Rag1−/− recipients 30d post-transfer. Dose response of HP-induced and Ag-induced memory cells IFN-γ production following re-stimulation with N4 (a,d), T4 (b,e) or G4 (c,f). Comparison of functional capacity of WT (g) or KO (h) Ag- and HP-induced memory cells. In all cases, lines represent means and dots values from individual mice. All data are representative of 1 of 2 repeated experiments (n=5 mice/group). NS – not significant, * p<0.05, ** p<0.01, *** p<0.001 by paired (a-f) or unpaired (g,h) Student’s t-test.