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. 2014 Jul 17;289(35):24079–24090. doi: 10.1074/jbc.M114.572503

FIGURE 6.

FIGURE 6.

Compounds that do not activate TRPV1. A, representative traces obtained at −120 and +120 mV initially (leak, gray), after 5 min of 5 μm glycerol phosphate (GP; red), and after 4 μm capsaicin (Caps, black). B, traces obtained as in A initially (gray), after 4 μm capsaicin (black) and after wash and 5 μm oleic acid (OA; red), and C, traces as in A and B. Initial currents are in gray, after 5 min of 5 μm of 1-C16 ether MG 1-O-hexadecyl-sn-glycerol (HG, red), and after 4 μm capsaicin (black). D, traces as in A–C. Initial currents are in gray, after 5 μm of FAP-9 in red, and after 4 μm capsaicin (black). E, traces as in A–C. Initial currents are in gray, after 5 μm of FAP-1 in blue, and after 4 μm capsaicin (black). F, horizontal line within each box indicates the median; boxes show the 25th and 75th percentiles, and whiskers show the 5th and 95th percentiles of the data obtained at +120 mV and normalized to activation by 4 μm capsaicin. None of these compounds, except FAP-1, activated TRPV1 (n = 6 for glycerol phosphate, 11 for oleic acid, 6 for glycerol phosphate, 5 for FAP-9, and 6 for FAP-1).