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Structure of ACOT12-ADP. A, the flexible regions 154–178 and 304–326 are visible in the ACOT12:ADP structure, revealing a 50° kink in the helix joining the two hotdog domains (loop I) at His150, causing residues 151–179 to link over the C-terminal α-helix. B, the hexamer arrangement of the ACOT12-ADP demonstrates its similarity to apo-ACOT12.
