TABLE 3.
AAR-induced Genes with the Greatest Degree of MEK Dependence
The 15 AAR-induced genes with the greatest degree of MEK dependence are shown. The expression microarray data are from HepG2 cells incubated for 8 h in DMEM ± histidine with or without 2.5 μm PD98059.
| Probe set ID | Gene symbol | Fold change (−His/DMEM) | p value (−His/DMEM) | Percentage of MEK dependence |
|---|---|---|---|---|
| JUC14003021.hg.1 | FOS | 11.7154 | 2.37E-07 | 88.6184 |
| PSR05009822.hg.1 | EGR1 | 23.8496 | 2.50E-13 | 88.3077 |
| PSR04005637.hg.1 | IL8 | 5.50397 | 9.82E-08 | 86.2509 |
| PSR10009587.hg.1 | DUSP5 | 2.44081 | 1.12E-09 | 82.6263 |
| PSR07004534.hg.1 | IGFBP1 | 2.11808 | 7.68E-05 | 80.4794 |
| JUC02011397.hg.1 | CCL20 | 2.73831 | 6.44E-10 | 80.0432 |
| JUC18005299.hg.1 | SERPINB8 | 2.29491 | 0.00177338 | 79.9067 |
| PSR09013309.hg.1 | AQP3 | 3.58114 | 3.36E-08 | 78.3926 |
| PSR22011280.hg.1 | LIF | 3.97938 | 2.96E-11 | 77.2063 |
| JUC01008446.hg.1 | MAB21L3 | 3.2181 | 1.47E-09 | 76.3792 |
| JUC03014269.hg.1 | FILIP1L | 2.22555 | 0.00718454 | 75.6935 |
| PSR05025990.hg.1 | SPRY4 | 3.24396 | 2.34E-09 | 75.0695 |
| JUC08008916.hg.1 | HEY1 | 3.2598 | 1.08E-08 | 75.0352 |
| JUC04002867.hg.1 | EREG | 9.82107 | 2.39E-08 | 74.9477 |
| JUC06000413.hg.1 | EDN1 | 2.84431 | 4.59E-06 | 74.6727 |