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Fluctuating regions in three pHLA complexes. a, fluctuating regions in HLA/VY8(P5A), HLA/VY8(L3A), and HLA/RY11(P8A) are shown as schematic drawings. The α-helices and β-strands in the peptide binding domain are shown in pink and light green, respectively. The fluctuating regions are circled with the name of the pockets. b, the kinetic rates and the populations of the major and minor states are visualized for the three pHLA complexes.
