Table 3.
Histopathological scoring of spleen sections.
| Mouse genotype | Treatment | Number of spleens examined | Number of normal spleens | Number of spleens exhibiting marked extramedullary hematopoeisis (EMH) only | Number of spleens exhibiting expansion of periarteriolar lymphatic sheaths (PALS) only | Number of spleens exhibiting both EMH and PALS |
|---|---|---|---|---|---|---|
| Experiment 1 | ||||||
| C57BL/6 IL-10−/− | control | 10 | 9/10 | 0/10 | 0/10 | 1/10a |
| infectedb | 18 | 14/18 | 1/18 | 1/18 | 2/18 | |
| C57BL/6 IL-10+/+ | infected | 10 | 9/10 | 0/10 | 1/10 | 0/10 |
| NOD IL-10−/− | control | 2 | 2/2 | 0/2 | 0/2 | 0/2 |
| infected | 10 | 3/10 | 1/10 | 1/10 | 5/10 | |
| NOD IL-10+/+ | infected | 10 | 7/10 | 1/10 | 0/10 | 2/10 |
| C3Bir IL-10−/− | control | 2 | 0/2 | 1/2a | 0/2 | 1/2a |
| infected | 9 | 5/9 | 0/9 | 0/9 | 4/9 | |
| C3H IL-10+/+ | control | 2 | 2/2 | 0/2 | 0/2 | 0/2 |
| infected | 10 | 9/10 | 0/10 | 1/10 | 0/10 | |
| Experiment 2 | ||||||
| C3Bir IL-10−/− | control | 5 | 2/5 | 0/5 | 1/5a | 2/5c |
| infected | 13 | 1/13 | 0/13 | 4/13 | 8/13 | |
| C3H IL-10+/+ | control | 5 | 4/5 | 0/5 | 1/5 | 0/5 |
| infected | 12 | 9/12 | 0/12 | 3/12 | 0/12 | |
| Experiment 3 | ||||||
| NOD IL-10−/− | control | 2 | 0/2 | 0/2 | 2/2 | 0/2 |
| infected | 2 | 1/2 | 0/2 | 1/2 | 0/2 | |
| NOD IL-10+/− | control | 2 | 1/2 | 0/2 | 1/2 | 0/2 |
| infected | 4 | 3/4 | 0/4 | 1/4 | 0/4 | |
| NOD IL-10+/+ | control | 7 | 1/7 | 0/7 | 6/7 | 0/7 |
| infected | 18 | 6/18 | 0/18 | 12/18 | 0/18 | |
a
This mouse had spontaneous colitis.
b
Includes mice on both 6% fat and 11% fat diets.
c
One of these mice had spontaneous colitis.