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. 2014 Aug 12;13:122. doi: 10.1186/s12933-014-0122-y

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© Soltysinska et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Echocardiographic assessment of left ventricular structure and mechanical function. A, Representative M-mode echocardiographic images of the left ventricle (LV) from anesthetized mice. LV cav: cavity; LVAW: anterior wall; LVPW: posterior wall. B, Fractional shortening of the LV. C, Left panel: Exemplary transmitral velocity-time curves with positive peaks representing flow velocities during passive early filling (E) and atrial contraction (A). Vertical lines indicate the demarcation of ejection time (ET), deceleration time (DT), isovolumetric relaxation time (IVRT) and isovolumetric contraction time (IVCT). Right panel: Deceleration phase of the E peak. *, P < 0.05, Student’s t-test.