Table 2.
Heart-rate variability parameters obtained in anesthetized control (db/+) and diabetic (db/db) mice before and after 16 hours fasting
| Db/+, fed | Db/db, fed | Db/+, fasted | Db/db, fasted | |
|---|---|---|---|---|
| RR, ms | 124 ± 4 | 131 ± 3 | 137 ± 4 † | 154 ± 4*† |
| HR, bpm | 483 ± 17 | 458 ± 12 | 438 ± 11 † | 390 ± 10*† |
| SDRR, ms | 4.4 ± 1.0 | 5.0 ± 0.9 | 5.3 ± 0.8 | 6.0 ± 1.6 |
| SD∆RR, ms | 2.1 ± 0.3 | 3.2 ± 0.6 | 2.8 ± 0.6 | 4.7 ± 0.7* |
| pRR6,% | 3 ± 4 | 11 ± 5a | 8 ± 3 | 22 ± 6* |
| LF Power, μs2 | 0.9 ± 0.2 | 0.9 ± 0.4 | 1.0 ± 0.4 | 2.5 ± 1.0 |
| HF Power, μs2 | 2.4 ± 0.6 | 7.9 ± 3.8 | 6.1 ± 3.4 | 15.4 ± 4.3a |
| LF Power, % | 32 ± 4 | 17 ± 4 | 17 ± 4 | 15 ± 5 |
| HF Power, % | 67 ± 4 | 84 ± 4 | 84 ± 4 | 86 ± 5 |
| LF/HF | 55 ± 11 | 25 ± 10 | 24 ± 9 | 19 ± 4 |
| n | 12 | 12 | 10 | 9 |
Abbreviations: HR (bpm) heart rate in beats per minute, SDRR standard deviation of RR intervals, SD∆RR standard deviation of the difference between successive RR intervals, pRR6 percentage of normal consecutive RR intervals differing by >6 ms, LF power absolute and normalized power contained within the low frequency range (0.15-1.5 Hz), HF power absolute and normalized power contained within the high frequency range (1.5-5.0 Hz). See reference [27]. Two-way ANOVA with a post hoc Bonferroni t test when appropriate. *, P < 0.05 versus db/+ mice; †, P < 0.05 versus fed mice of the same genotype; a, P = 0.063 versus db/+. One mouse was excluded from the db/+, fasted group due to technical difficulties with anesthesia.