Table 4.
Ratios of p75 NTR /Trks in hippocampal subfields of MTLE groups and normal controls
| MTLE | MTLE + D | MTLE + P | Controls | p value | |
|---|---|---|---|---|---|
| TrkA | |||||
| Granular layer | 2.4 ± 1.1 | 1.4 ± 0.4 | 2.1 ± 1.4 | 1.0 ± 0.5 | 0.04 (MTLE × CTRL) |
| Hilus | 2.3 ± 2.0 | 1.4 ± 0.5 | 1.5 ± 0.5 | 0.8 ± 0.4 | 0.04 (MTLE × CTRL) |
| CA4 | 1.9 ± 0.8 | 1.4 ± 0.4 | 1.9 ± 0.6 | 0.9 ± 0.3 | 0.04 (MTLE and MTLE + P × CTRL) |
| CA3 | 1.9 ± 1.0 | 2.3 ± 0.9 | 2.6 ± 1.0 | 1.1 ± 0.6 | n.s. |
| CA2 | 2.6 ± 1.2 | 1.7 ± 0.5 | 2.1 ± 0.6 | 1.1 ± 0.6 | 0.04 (MTLE x CTRL) |
| CA1 | 2.6 ± 1.4 | 2.6 ± 0.9 | 2.3 ± 1.1 | 0.9 ± 0.5 | 0.04 (MTLE and MTLE + D × CTRL) |
| Prosubiculum | 2.1 ± 1.2 | 2.1 ± 1.0 | 1.9 ± 0.3 | 1.0 ± 0.4 | n.s. |
| Subiculum | 2.3 ± 1.0 | 1.5 ± 0.5 | 1.8 ± 0.6 | 0.9 ± 0.5 | 0.005 (MTLE x CTRL) |
| Parasubiculum | 2.2 ± 0.6 | 2.3 ± 0.6 | 1.8 ± 0.4 | 1.1 ± 0.5 | 0.004 (MTLE and MTLE + D × CTRL) |
| Entorhinal cortex | 2.3 ± 0.8 | 3.5 ± 2.1 | 2.4 ± 1.0 | 0.9 ± 0.4 | 0.02 (MTLE + D × CTRL) |
| TrkB | |||||
| Granular layer | 2.2 ± 0.9 | 0.9 ± 0.5 | 0.8 ± 0.5 | 0.6 ± 0.2 | <0.0001 (MTLE × all groups) |
| Hilus | 1.6 ± 1.1 | 0.9 ± 0.4 | 0.7 ± 0.2 | 0.6 ± 0.1 | 0.01 (MTLE × MTLE + P); 0.02 (MTLE × CTRL) |
| CA4 | 2.1 ± 1.0 | 0.9 ± 0.4 | 0.8 ± 0.2 | 0.5 ± 0.1 | <0.003 (MTLE × all groups) |
| CA3 | 1.7 ± 0.9 | 2.0 ± 1.0 | 1.0 ± 0.4 | 0.6 ± 0.2 | 0.04 (MTLE and MTLE + D × CTRL) |
| CA2 | 2.1 ± 1.3 | 1.3 ± 0.4 | 1.1 ± 0.2 | 0.6 ± 0.1 | 0.01 (MTLE × CTRL) |
| CA1 | 2.1 ± 0.8 | 1.5 ± 0.4 | 1.5 ± 0.5 | 0.6 ± 0.2 | <0.0001 (MTLE × CTRL) |
| Prosubiculum | 2.1 ± 0.5 | 1.4 ± 0.4 | 1.2 ± 0.3 | 0.7 ± 0.1 | <0.01 (MTLE × all groups); 0.03 (MTLE + D × CTRL) |
| Subiculum | 2.1 ± 0.8 | 1.0 ± 0.4 | 0.9 ± 0.3 | 0.6 ± 0.3 | <0.0001 (MTLE × all groups) |
| Parasubiculum | 2.3 ± 0.7 | 1.2 ± 0.4 | 1.0 ± 0.2 | 0.6 ± 0.2 | <0.0001 (MTLE × all groups) |
| Entorhinal cortex | 1.9 ± 0.4 | 1.1 ± 0.4 | 1.3 ± 0.4 | 0.5 ± 0.1 | 0.01 (MTLE × MTLE + D); <0.01 (MTLE groups × CTRL) |
| TrkC | |||||
| Granular layer | 3.4 ± 1.7 | 3.0 ± 1.1 | 2.9 ± 1.2 | 1.6 ± 0.7 | <0.01 (MTLE groups × CTRL) |
| Hilus | 2.0 ± 1.0 | 1.5 ± 0.5 | 1.6 ± 0.3 | 0.8 ± 0.2 | 0.009 (MTLE × CTRL) |
| CA4 | 2.3 ± 1.2 | 1.6 ± 0.6 | 1.7 ± 0.6 | 1.0 ± 0.4 | n.s. |
| CA3 | 2.0 ± 0.7 | 2.4 ± 0.4 | 1.7 ± 0.4 | 1.1 ± 0.5 | <0.01 (MTLE and MTLE + D × CTRL) |
| CA2 | 2.2 ± 0.8 | 2.4 ± 0.4 | 1.7 ± 0.4 | 1.1 ± 0.5 | 0.02 (MTLE and MTLE + D × CTRL) |
| CA1 | 2.9 ± 1.3 | 2.7 ± 1.8 | 2.4 ± 0.7 | 1.3 ± 0.7 | n.s. |
| Prosubiculum | 2.2 ± 1.1 | 1.7 ± 0.4 | 2.2 ± 1.0 | 1.7 ± 1.2 | n.s. |
| Subiculum | 2.7 ± 1.1 | 2.1 ± 0.5 | 2.2 ± 1.3 | 1.1 ± 0.3 | n.s. |
| Parasubiculum | 2.7 ± 0.5 | 2.7 ± 0.5 | 2.4 ± 0.8 | 1.3 ± 0.5 | <0.01 (MTLE groups × CTRL) |
| Entorhinal cortex | 2.2 ± 0.5 | 2.4 ± 0.9 | 2.9 ± 1.0 | 1.1 ± 0.5 | 0.03 (MTLE + P × CTRL) |
Values indicated as mean ± std. deviation. n.s.: non-significant.